Overcoming Obstacles Essay Topics Reviews & Guide

Overcoming Obstacles Essay Topics Reviews & Guide Overcoming Obstacles Essay Topics Secrets There's a trail by my house I go to regularly. While you might have spent a great deal of time working on your goals for the next calendar year, there are lots of things which are going to become in your way to achieving them. Because college isn't likely to be smooth sailing and you're anticipated to manage challenging situations all on your own. If you recognize the kind of obstacle you're addressing, it is going to help to prevent you from veering off course, and at times, never getting back on course. You should encourage yourself when trying to accomplish your objectives, even if people aren't encouraging and supporting you. A lot of people give up just before the break through and lose out on a valuable prospect. Losing'' customers'' is a significant source of lost income for the majority of businesses. Do your research, and that means you know what questions to stay in mind. To have the ability to take a look at a bad or mundane circumstance and help it become better. If your response is less that 7 you are not likely to follow this up completely. To guarantee that you will see a complete answer to every question, we've got a support team that is always online. A setback may be an career-ending injury, and it may also be a not getting the funding you were promised for an undertaking. Now you have really defined your goal you're prepared to go. You're able to fail to make the very first team. Education plays a significant role in the life span of the authors. Why Almost Everything You've Learned About Overcoming Obstacles Essay Topics Is Wrong Individuals that are successful at building a change are the people who will willingly overcome their fears, doubts and insecurities so as to make it take place. Every person has been faced with things that shape their character mor e often than once in the course of their life. A lot of people start out making goals only for the interest of making them. Other People Quite frequently the people which are closest to us fear us achieving our targets. The journey of self change may consist of different journeys like the exploration of new and unfamiliar perspectives that have the possibility of introducing us to new suggestions and perceptions which then have the capability to open our minds to more new ideas. Nowadays it's very difficult to locate a trustworthy essay writing service. The perfect way to move forward on your own path is to realize the possible obstacles and plan in advance how you are going to address them! Since you understand what the end resembles, you will work through all the obstacles and challenges that you encounter on the way. Fear isn't anything more than a negative thought, which results in negative emotions, which then makes a physical manifestation within your body. Another kind of fear is the fear of succeeding. Men and women using fear in a try to control you are most likely insecure. You only require perseverance and patience. Simply take a minute immediately to reflect back on a number of the setbacks you have experienced in your life. To be prosperous in changing career paths, you must learn how to overcome obstacles you will encounter on the way. When you are confronted with negative obstacles, developing a positive story that you may read and listen to regularly re-energizes you. The Basics of Overcoming Obstacles Essay Topics Fear is an all potent controller. You have to monitor your ideas and take the action needed to secure you where you would like to be. When it can be a rather moving topic, it may also be too personal too share. Share your targets and be as clear as possible. Seeing your success is a rather strong tool.

The Juvenile Justice System Is A State Level System Of...

Today in the United States, citizens under the age of 18 are considered minors. In our criminal justice system, about 1 million juveniles under the age of 18 are arrested each year. While violent crimes by juveniles are decreasing, the female juvenile population has grown tremendously. Both girls and boys who are in the juvenile system usually have problems at home and school that have put them at risk for delinquency. This includes maltreatment, poverty or both, and these factors may have a negative impact on their adjustment to adulthood. In the state of Connecticut, the juvenile justice system is a state level system of juvenile courts, detention centers, private residential facilities and juvenile correctional facilities. In Connecticut, the Superior Court for Juvenile Matters has exclusive original jurisdiction over juveniles accused acts. Delinquents are children, prior to their eighteenth birthdays, who have violated or attempted to violate any federal or state law, order of the Superior Court, or any local or municipal ordinance. Although the same criminal statutes apply to both adults and juveniles, in most cases juveniles are subject to different procedures than adults. When a child is presented into the system, their first encounter occurs with a police officer. Police officers have a wide discretion when it comes to juveniles. Police can make the decision to issue a warning and release the juvenile, speak with parents and release them, make a referral to aShow MoreRelatedThe U.S. Census reported that 1.6 million individuals under the age of 18 were arrested in 2010, a700 Words   |  3 Pagesof 18 were arrested in 2010, a substantial increase from previous years (OJJDP, 2012; US Census Bureau, 2012). Of those individuals detained, over nine percent were convicted as juveniles and entered into a juvenile detention facility (Risler, 2009). Approximately 500,000 children are currently in the foster care system, while almost 300,000 have medical probl ems, have neurological impairs, and developmental delays (Earls, 2013). In addition, they were all exposed to some degree of critical abuseRead MoreJuvenile Justice Facilities : Protecting The Health And Wellness Of Our Youngest Inmates1370 Words   |  6 PagesPREA Mandates in Juvenile Justice Facilities: Protecting the Health and Wellness of our Youngest Inmates Jennifer Hulvat Kaplan University, J.D. Full Time Faculty March, 2015 The month of April brings a change of seasons around the country, and a new focus issue to the table; Health and Wellness. In the area of Juvenile Corrections, we might take this opportunity to revisit a topic I wrote about in February, â€Å"Incarcerated Youth at Risk: Is Your Facility Doing Enough to Avoid Liability?† UltimatelyRead MoreDo Incarcerated Youth Get The Education They Need?913 Words   |  4 Pagespost-secondary education, employment, and wellbeing in adulthood. Historically, one group of students in the United States has received grossly inadequate education: children in juvenile correctional facilities. Little to nothing is known about educational programs in juvenile detention centers. Limited information is available on best practices for educating youth in the juvenile justice system whether committed or detained. Koyama cites that existing empirically based educational practices do not readilyRead MoreJuvenile Delinquency And Juvenile Criminal Justice System1475 Words   |  6 PagesIntroduction: Juvenile delinquency is an ever growing issue in the United States, according to the Office of Juvenile Justice and Delinquency Prevention, â€Å"In 2012, there were 3,941 arrests for every 100,000 youths ages 10 through 17 in the United States† (OJJDP, 2014). The way juveniles are treated in the criminal justice system is very different than the way adults are. In 1899, in Cook County, Illinois, the first juvenile justice system in the country was founded. This established an alternativeRead MoreShould Adult Offenders Be Allowed?933 Words   |  4 PagesThroughout the United States, thousands of children have been sentenced as adults and sent to adult prisons. Without the possibility of parole, nearly 3000 kids nationwide have been sentence to life in prison. Children as young as 13 years old have been tried as adults and sentenced to die in prison, usually without any consideration of their age or facts or conditions that surround the offense. Trying teens as adults gives w ay to many opinions. The researcher believes minors should be up-held toRead MoreMinority Minorities And The Juvenile Justice System900 Words   |  4 PagesDisproportionate Minority Contact Minority children are exposed to the juvenile justice system at a higher percentage than their white peers. Minority children are over represented at every level of the judicial process. Minority children are more likely to be charged, detained, and confined. The proportion of minorities increases as each level becomes more restrictive. Research also indicates that minority children receive harsher treatment than Caucasian children do. Minority children are moreRead MoreJuvenile Vs. Adult Corrections939 Words   |  4 PagesJuvenile vs. Adult Corrections The correctional justice system of the United States focused to keep crime out of the streets. The age group divides once the criminal becomes eighteen or above, but sometimes the lines are drawn at the age eighteen to determine if the criminal is convicted of a crime as a juvenile or as an adult. The system allows a rehabilitation facility to maintain criminals from relapsing an offense they have done or will do in the future. Although, criminals charged as an adultRead MoreCommunity Based Corrections Essay example1108 Words   |  5 PagesCommunity based corrections is a program which supervises people who have been convicted or are facing conviction. It is a non-incarcerate system of correction. These offenders have been convicted or are facing conviction. Some offenders have entered these programs before being in jail and some serve a part of their sentence in jail before entering the program. The goals of the community based corrections would be one of providing guidance, program opportunities and support to the offender’sRead MoreShould People Less Than Eighteen Years Old (Minors/Juveniles/Adolescents) Ever Be Tried and Sentenced as Adults?1516 Words   |  7 PagesShould people less than eighteen years old (minors/juveniles/adolescents) ever be tried and sentenced as adults? The legislation of trying and sentencing youth criminals under adult justice system has been a hot topic of debate. Supporters of tough laws on insist the need to enforce harsh penalties to uphold justice. The practice of treating youth criminals as adults since the 1990s is a result of the steep rise in youth crimes. However, youth advocates argue that tough laws should not be appliedRead MoreA Brief Note On Academic And Professional Communications1471 Words   |  6 Pagesfaced by both federal and state run facilities, however, as the privatization of correctional facilities became more prevalent, so too did instances of corruption. As more federal and state run institutions became privatized there was a marked increase in numbers of those incarcerated as well as a push for more stringent sentencing of those convicted of committing a crime. This has resulted in those companies responsible for running these facilities taking advantage of a system originally set up to house

The Placebo Effect free essay sample

A placebo is basically a control substance when testing for something else. For instance a company is testing their protein shakes and they have a person do a lifting workout and then drink a protein shake. To see that it works they will sometimes mix in the placebo. The placebo is actually just a control that has none of the protein in it, yet the person does not know that. This is how the placebo effect came about. In many of these experiments it was found that the placebo did not throw off the actual substance because the person still thought they were getting the beneficial substance. When they knew that they were getting a control substance their performance did incline with the protein and did not when they were receiving the placebo. There has been many experiments now, trying to understand why this happens. Caffeine has been tested by weightlifting, testosterone with aggressiveness, performance-enhancing shots, and even sports clothing with performance. So is it a certain product we are using that helps us perform better or possibly just the products of our own mind? There has been much research to find out. Caffeine is a popular substance that is supposed to enhance sport performance. There have been many tests that show that it does work by using a placebo, yet the problem is that there are also many tests that show something else. A control group is used with the assumption that the placebo is inactive. There was never supposed to be anything such as the placebo effect. Also the subjects in the experiments were not supposed to act differently when they thought they were or were not taking it. To figure things out scientists in the United Kingdom designed an experiment with the placebo effect on weight lifting. Fifteen males with lifting experience were recruited. Scientists told the men that they were in a study on the effects of caffeine on weightlifting performance. They also told them that they would be consuming two solutions, one containing caffeine and the other a placebo in random order, yet they were actually getting two placebos. The subjects came to the lab three different days all between 9a. m and 12p. m (â€Å"Placebo Power†). For the first visit the subjects tested their maximum strength one rep max on single leg extensions. The second day the subjects all warmed up for five minutes cycling and then tested. They did one set of single leg extensions until failure at sixty percent of their one rep max. All repetitions were counted and the trials were separated by one to three days. All of the data and feedback was noted. The total amount of weight was counted (repetitions multiplied by weight), and the perceived exertion rate (RPE, the measure of work the subjects thought they were putting in) was determined (â€Å"Placebo Power†). To the subjects all three trials were different. In one trial, the control trial, the subjects consumed nothing. In the other two trials the subjects did consume a pill an hour before the trial but they did not know what it was. They were told that they were receiving a caffeine pill on one of the days and a placebo on the other, yet they got a placebo for both trials. Even more, the researchers that interacted with the subjects did not even know the true nature of the research and that there was no caffeine ever used until the end of the study. After all of the trials the subjects were given a questionnaire asking which trial they thought they received the placebo and which day they received the caffeine. After the result analysis researchers found that the subjects completed an average of 4. 1 more reps when they thought they had taken caffeine before the trial as opposed to when they thought that they took the placebo (â€Å"Placebo Power†). As for the total weight lifted, 306 lbs. more was lifted on average when the subjects thought they had consumed caffeine (â€Å"Placebo Power†). As regards to RPE, the subjects were higher when they thought that they had gotten the placebo for the trial instead of the caffeine or the control trial. What that indicated was that the subjects thought that they had to work much harder to lift the weight when they thought they had just taken a placebo. Of the fifteen subjects thirteen of them said that they had expected the caffeine to enhance their weightlifting performance. From this study it is clear that expectation is everything. When someone expects for caffeine to enhance their workout then it will whether it’s a placebo or not. When the subjects thought they were getting caffeine they lifted more weight and did more repetitions on average. Also when they thought they were receiving the placebo they expected to have to work harder in order to reach their previous goals. In another study about testosterone and aggressiveness a placebo effect was found. There were three groups of male athletes from a university. There was a control group, a testosterone group, and a placebo group where they were told they were getting testosterone but really got nothing. The subjects were all interviewed about how they were feeling and also tested physically. There was definitely a placebo effect found but also a big surprise of the effects of actual testosterone. With the self-estimated data of the feeling of anger and irritation both graphs looked the same. The control group said that they did not notice any changes. The placebo group noticed many changes. On average the levels of anger and irritation went way up (Bjorkqvist,2010). One man said that he and friends noticed him being on edge and very irritable (Bjorkqvist,2010). Physically he said that he felt better than ever. Not only did he think that his body was able to work harder and lift more weight effortlessly, he also said that he became more self-confident in competition. The most interesting thing in this experiment was the effects of the testosterone, or should I say lack of effect. The group that actually received the testosterone said in their self evaluations about anger and irritability that they noticed no change. Before the treatment, before the exercise, and after the exercise they said that they stayed the same behaviorally. The difference that was found was in what they thought about how they were able to work physically. They all on average thought that the testosterone had enhanced their physical performance (Bjorkqvist,2010). In reality the data that was collected in all of the tests showed that physically all of the groups showed no differences. There were no enhancements or weaknesses. Although there was a definite placebo effect found, it differs completely. In the first experiment, the placebo effect was shown in self evaluation and also with data from weightlifting. In the second experiment, the only changes were with the placebo group in the self evaluation. There could be many expectation factors that make this experiment have a questionable outcome. Some may want the testosterone to have positive effects by saying that they experienced enhanced physical performance and no negative personality traits that have been accused before. There is a question mark at the end of this experiment on everything but the placebo effect. The placebo effect can be seen with anything. It is not necessarily always an oral intake of a substance, it could even be clothing. For swimmers, their suits may mean the difference in winning and losing. A swimmer may take a while to get suited up but it is for a good reason. The said new and improved speed suit covers the body from shoulders to ankles and is tighter than skin tight. The reason these suits are so important is because it reduced jiggle. The more jiggle a swimmer has, the more time it takes for their body to move through the water (Barone,2008). These suits are said to condense the breasts and buttocks for less drag. In an experiment with the placebo effect in sports wear a professional swimmer was tested. This swimmer was known to always buy the latest â€Å"performance enhancing† suits and did believe in them. The suit brands are very careful with their claims now. These suits were supposed to reduce drag and nothing else. The speed enhancement was just assumed. Science shows that a suit may be able to shave of a fraction of a second traditionally so for this experiment that was the hypothesis of the scientist (Barone,2008). The actual conclusion was quite different though. The swimmer ate what he normally would before a meet and did the same warm up. The timer started and the swimmer was off. Seems that the swimmer was quite a positive thinker because it turned out that he shaved over an unheard of fifteen seconds off his time (Barone,2008). The placebo effect is shown because statistically swimwear would not be able to make that huge of a marginal change. The placebo has been proven to work in pain killing more than anything (â€Å"How To Cheat Without Cheating†). A scientist once saw research of people that had been injected with morphine for two days saw pain relief for those two days and also after that when they were injected with nothing but a placebo. This led him to test it in sports performance. He and colleagues simulated a tournament of four teams of athletic men in pain endurance competitions. In one their forearm was strapped with a tourniquet as they squeezed a hand spring repeatedly until pain forced them to stop. All of the scores were taken and averaged over the whole team. One of the teams was injected with morphine two weeks before the competition and also one week before and then on the big day they got saline solution thinking they were still receiving morphine. This is the legal way to use them. Another team was injected with saline that was combined with an opiate-blocking drug. The other two teams received no treatment at all but one with a placebo on competition day. The team that received morphine and then the placebo on competition day endured a lot more pain than the other three groups. The group injected with the mixed saline did no better than to two control groups (â€Å"How To Cheat Without Cheating†). What this show is that the placebos actually do reduce pain because the person believes that it does. The brain is encouraged to produce more natural opiates than customary (â€Å"How To Cheat Without Cheating†). The placebo effect has been proven in many different ways. Even if the conclusions about the other groups they were tested are not accurate the placebo effect was accurate. The placebo effect is actually just a mind effect. I think an athlete wants to see enhancement of performance whether they are actually getting a substance or not as long as it is legal. Whether it is the brain or biology the placebo effect is real.

Trickster Online Personality Quiz free essay sample

You can hide, throw landmines, and scare people with your amazing speed! You are a pure ninja fox – the thief master! You mastered the arts of hidden weapons, and now the techniques of ninja hiding! Sneak up to your opponents and surprise them!   You are a pure buffalo, the gladiator! Buffalos get AoEs, but that doesn’t mean they’re not strong! They can do more then 60,000 damage with the right equips! You are a pure bunny, the champion! Bunnies may seem harmless in the real world, but in trickster, they can do more then buffalos if prepared properly! They focus more on single targets!   You are a hybrid dragon – the wizard! You are the master of fire, lightning, and dark. We will write a custom essay sample on Trickster Online Personality Quiz or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page The most strongest spells are from those elements! You are a hybrid dragon – the wizard! You are the master of wind, earth, and light. These elements have awesome AoEs and hot looking spells! You are a hybrid dragon – the wizard! You are the master of water, lightning, and dark. All these elements makes you quite the annoyer to monsters and other tricksters alike! You are a hybrid dragon – the wizard! You are the master of†¦. fire and earth? Although at first they don’t seem to compliment each other, but they just somehow work! Join the dark side for extra power, or the light side for more defensive spells! You are a hybrid dragon – the wizard! You are the master of wind and water! You can be fast or slow, weak or strong, or AoE and single target all in one! Join the dark side for extra power, or the light side for more defensive spells! You are a hybrid sheep – the witch! You are the master of fire, lightning, and dark. The most strongest spells are from those elements!   You are a hybrid sheep – the witch! You are the master of wind, earth, and light. These elements have awesome AoEs and hot looking spells!   You are a hybrid sheep – the witch! You are the master of water, lightning, and dark. All these elements makes you quite the annoyer to monsters and other tricksters alike!   You are a hybrid sheep – the witch! You are the master of†¦. fire and earth? Although at first they don’t seem to compliment each other, but they just somehow work! Join the dark side for extra power, or the light side for more defensive spells!   You are a hybrid sheep – the witch! You are the master of wind and water! You can be fast and slow, weak and strong, and AoE and single target all in one! Join the dark side for extra power, or the light side for more defensive spells! You are a priest, the holy dragon! God has given you the power to defend your party and yourself! But you can also pack quite a punch! It can be very hard for a trickster to take you down!   You are a dark lord, the evil dragon! You take down monsters with your black magic of doom†¦muahahahaha!   You are the sheep soul master! You take down enemies with fire and deadly lightning! These elements are very strong! You are the sheep soul master! You bend nature’s elements wind and earth to your will! Create earthquakes and tornadoes whenever you feel like it! Yay!   You are the sheep soul master! You control water and lightning, and when used together, you trap your enemy! Keep attacking them to stop them from moving until they die!   You are the sheep soul master! You turn land to lava, and rocks to muddy swamps! Dirty and burn your enemies down!   You are the sheep soul master! You use water and wind as your elements of choice. Have a picnic in the middle of a war by protecting yourself with whirlwinds and freezing your enemies! You are a lion – or the mad scientist! You have mastered the gun and now you can go crazy and shoot monsters and tricksters down! Muahahahaha! You are a hybrid lion – the cyber hunter! You act as a ninja and throw hidden weapons! You can throw it wide, or single, or multiple, or chain†¦. whatever you like!   You are a hybrid lion – the cyber hunter! But you didn’t go cyber hunter for throwing weapons! No! You went hybrid because you felt like it! I went for this job, and I didn’t regret it one little bit! You are a hybrid lion – the cyber hunter! But you didn’t go cyber hunter for throwing weapons! No! You went hybrid because you want the extra luck to make you damage excel others! Good luck! You are a hybrid fox, the hunter lord! You add all you points into accuracy and get gun skills. You are the girl of a hybrid sense!   You are the duke of trickster, the hybrid raccoon! You can transform into a deadly werewolf! And you can also†¦dance? Wow! A dancing werewolf!   You are a gambler, the pure raccoon! You don’t just gamble for money, you gamble to defeat enemies by throwing cards! More deadly than paper cuts!   You are a card throwing diva! You are the hybrid cat that not only throws cards, but turns into a werecat! Rip those enemies apart! Go, go, go!   You are a singing diva hybrid cat! Sing for your life! Sing for your teammates! Sing to kill monsters! Sing to†¦. you get the idea.   You are the pure cat – primadonna! Wink at magic types to stop them from casting spells, then two-step dance them while they’re disabled! Slap, slap, kick!   You are the very few†¦slapping magic types? You do incredibly high damage? You can heal yourself? And cast magic at will? Wow, you must have high determination to get through this character!

Quote vs. Quotation, Invite vs. Invitation

Quote vs. Quotation, Invite vs. Invitation Quote vs. Quotation, Invite vs. Invitation Quote vs. Quotation, Invite vs. Invitation By Maeve Maddox One of my college professors insisted that quote is a verb and quotation is a noun and never the twain shall meet. For example, a writer quotes from an author, but the quoted material is a quotation, never â€Å"a quote.† Although I still observe the distinction in my own writing, I have become aware that both the OED and Merriam-Webster recognize the use of quote as a noun. Most English words ending in -tion have French cognates, for example: information, confirmation, and position. Such words came into English in the Middle Ages from French. In M.E. the ending of these French borrowings was spelled -cioun; later the ending came to be spelled -tion in both languages. Through the centuries, many -tion words have lost their endings, and more are in the process of doing so. English words ending in -tion tend to lose the suffix when the first part of the word retains the word’s meaning without it. Here are some shortened -tion nouns that have become accepted into standard English: quote from quotation ID or I.D. from identification insert from insertion Here are some that the OED still labels colloquial or slang: invite from invitation info from information admin from administration prep from preparation promo from promotion (in the sense of publicity) ammo from ammunition NOTE: M-W does not agree with OED on all of the shortened -tion words. For example, while M-W labels the noun invite â€Å"chiefly dialectal,† it admits ammo as a standard word. OED does not have an entry for specs with the meaning specifications, but M-W has. Many speakers cringe when they hear or read invite used as a noun, but the tendency to drop -tion when the rest of the word is sufficiently meaningful without it, is strong in English. I may not like hearing invite used as a noun, but enough speakers use it that way for it to make a comeback. Yes, comeback: 1659  Ã‚   H. LEstrange Alliance Divine Offices 326  Ã‚   Bishop Cranmer..gives him an earnest invite to England. OED documentation. A second tendency with -tion words that I find it difficult to accept with equanimity concerns verbs. The function of the suffix -tion is to change a verb into a noun: examine/examination, locate/location, converse/conversation, interpret/interpretation. Some speakers, however, perhaps because they are not familiar with the underlying verb, create a new verb via back formation. For these speakers, orientation become orientate; interpretation becomes interpretate, and conversation becomes conversate. NOTE: Back-formation is the formation of what looks like a root-word from an already existing word which might be (but is not) a derivative of the former. Of the words I just listed, orientate has become standard in British English, but it is still regarded as nonstandard in American English. Interpretate does appear in the OED, but it is labelled â€Å"rare or obsolete†; the most recent example of its use is dated 1866. Want to improve your English in five minutes a day? Get a subscription and start receiving our writing tips and exercises daily! Keep learning! Browse the Spelling category, check our popular posts, or choose a related post below:50 Idioms About Legs, Feet, and ToesDoes "Mr" Take a Period?20 Ways to Cry

The Mausoleum at Halicarnassus

The Mausoleum at Halicarnassus The Mausoleum at Halicarnassus was a large and ornate mausoleum built both to honor and hold the remains of Mausolus of Caria. When Mausolus died in 353 BCE, his wife Artemisia ordered the construction of this vast structure in their capital city, Halicarnassus (now called Bodrum) in modern Turkey.  Ã‚  Ultimately, both Mausolus and Artemisia were buried inside. The Mausoleum, considered one of the Seven  Ancient Wonders of the World,  retained its grandeur for nearly 1,800 years, until earthquakes in the 15th century destroyed part of the structure. Eventually, nearly all of the stone was taken away  to be used in nearby building projects,  particularly for  a Crusader castle. Who Was Mausolus? Upon the death of his father in 377 BCE, Mausolus  became the satrap (a  regional governor  in the Persian Empire)  for Caria. Although only a satrap, Mausolus was like a  king in his realm,  ruling for 24 years. Mausolus was descended from the indigenous herdsmen of the area, called Carians, but appreciated Greek culture and society. Thus, Mausolus encouraged  the Carians to  leave  their lives as  herdsmen and embrace the Greek way of life. Mausolus was also  all about expansion. He moved his capital city from Mylasa to the coastal city of Halicarnassus and then worked on a  number of projects to  beautify the city, including building a large palace for himself. Mausolus  was also politically savy and was thus able to add several nearby cities to his  realm. When Mausolus died in 353 BCE, his wife Artemisia, who also happened to be his sister, was grief stricken. She wanted the most beautiful tomb built for her departed husband. Sparing no expense, she hired the very best sculptors and architects  that money could buy. It is unfortunate that Artemisia died just two years after her husband, in 351 BCE, not seeing the Mausoleum of Halicarnassus completed. What Did the Mausoleum of Halicarnassus Look Like? Built from  about 353 to 350 BCE, there were five famous sculptors that worked on the exquisite tomb. Each sculptor had a portion that they were responsible for   Bryaxis (north side), Scopas (east side), Timotheus (south side), and Leochares (west side). The chariot on top was  created by Pythis. The structure of the Mausoleum was made up of three parts: a  square base on the bottom, 36 columns (9 on each side) in the middle, and then topped by a stepped pyramid that had 24 steps. All of this was covered in ornate carvings, with life-size and larger-than-life statues abounding. At the very top was the piece de resistance the chariot. This 25-foot-high marble sculpture consisted of standing  statues of both Mausolus and Artemisia riding in a chariot pulled by four horses. Much of the Mausoleum was made out of marble and the entire structure reached 140 feet high. Although large, the Mausoleum of Halicarnassus was known more for its ornate sculptures and carvings. Most of these were painted in vibrant colors. There were also friezes that wrapped around the entire building. These were extremely detailed and included scenes of battle and hunting, as well as scenes  from Greek mythology that included such mythic animals as centaurs. The Collapse After 1,800 years,  the long-lasting Mausoleum was destroyed by earthquakes that occurred  during the 15th century CE in the region.   During and after that time,  much of the marble was carried away in order to build other buildings, most especially a Crusader fortress held by the Knights of St. John.   Some of the elaborate sculptures were moved into the fortress as decoration. In 1522 CE, the crypt that for so long had safely held the remains of Mausolus and Artemisia was raided. Over time, people forgot exactly where the Mausoleum of Halicarnassus had stood. Houses were built on top. In the 1850s, British archaeologist Charles Newton recognized that some of the decorations at Bodrum Castle, as the Crusader fortress was now called, could have been from the famous Mausoleum. After studying the area and excavating, Newton found the  site of the Mausoleum.  Today, the British Museum in London contains statues and relief slabs from the Mausoleum of Halicarnassus.  Ã‚   Mausoleums Today Interestingly, the modern word mausoleum, which means a building used as a tomb, comes from the name Mausolus, for whom this wonder of the world was named. The tradition of creating mausoleums in cemeteries continues around the world today.  Families and individuals build mausoleums, both large and small,  in their own or others honor following their deaths.   In addition to these more  common mausoleums,  there are other, larger mausoleums that are tourist attractions today.   The worlds most famous mausoleum is the Taj Mahal in India.

The Legalization Of Genetically Choosing The Feature of Child Research Paper

The Legalization Of Genetically Choosing The Feature of Child - Research Paper Example It is therefore not a new striking issue to finally end up with concern about the legalization of genetically choosing the feature of one’s own child. This is due to the fact that humans aim at improving ways in order to eliminate various negative health concerns of the humanity. One substantial proof is the ongoing studies or research and implementation of stem cells technology which at some point is aimed at trying to combat various hereditary defects and even future diseases in humans. Genetically choosing the feature of a child would make sense after all. These studies in addressing human health concerns are essentials for the human survival, but the actual implementation of their results may probably pose significant challenges and disadvantages that at some point may only be beneficial for the powerful few. At this point, I will state the promises or advantages of genetically choosing the feature of a child based on the results of genetic modifications in various animals , plants, and organisms (Reuter et al. 989; Kim et al. 534; Jang et al. 2011; Kilic and Akay 1164). The study of Reuter et al is about identifying the importance of herbicide resistant plant which the bottom line has a significant implication on protecting the environment in a wide scale. Kim et al’s research aims at understanding the therapeutic effects of genetically modified neural stem cells which found remarkable evidence of future advantage. The investigation of Jang et al has positive implications on the advantages of genetic modification on mass production of agricultural products. Finally, Kilic and Akay investigated the potential effect of transgenic crop (Bt corn) on health, but found no substantial evidence on rats. Based on the above evidences and results of different mentioned studies, there is a remarkable reason to believe that genetic modification of child’s character would also lead to success and substantial benefits especially in eradicating those h armful features causing negative impacts on human health and survival in general. I plan to point out that although there are remarkable advantages in genetic modification, its main application should only be confined and limited to plants, animals and organisms but not on humans. SUBCLAIMS: The issue about genetic modification is so complex that it is not only confined in purely scientific concerns but it involves the whole aspects of humanity. Thus, among the most important issues that are integrated in genetic modifications are social, political and economic. 1. Choosing a feature of a child via genetic modification is a great social concern. a. In here, I would include studies claiming that genetic modifications have significant benefits for the humanity which leads to positive acceptance of it. b. Particularly, I would employ the study of Guehlstorf and Hallstrom on â€Å"The role of culture in risk regulations: a comparative case study of genetically modified corn in the Unit ed States of America and European Union.†. This specifically points out the different stand of the US and European nations on genetic modification. For example, the stand of Germany on genetic modification (Christoph, Bruhn and Roosen, â€Å"Knowledge, attitudes towards and acceptability of genetic modification in Germany.†). c. I would specifically point out that the varying stand on genetic modification is a bottom line issue in line with social concern. In here, I would emphasize that due to different perspectives in looking at genetic

STEP ONE - Voice Due Week 4 Essay Example | Topics and Well Written Essays - 1250 words

STEP ONE - Voice Due Week 4 - Essay Example government through the seizure of black hills in Dakota (Nabokov 26) The voice goes ahead to describe the detailed story of the longest legal struggle in American legal history and the betrayal by the United States government. This is illustrated by the signing of a peace treaty between the United States government and Sioux Nation promising a safe homeland. The treaty also included the ownership of the black hills. When gold was discovered at the black hills later, the government sought to have the land back. The white owned company violated the treaty by literally scrambling for the precious metal. Even though the Sioux Indians protested against this act, there was nothing they could do as the United States government declared war and took the land back. The Sioux were forced to go to a White man’s court to seek resolution as there was no alternative (Sutton 43). The issues that Edward Lazarus addresses in this book are betrayal and injustice. This is very well illustrated by the United States government action to renege on the treaty that gave the black hills to Sioux Indians. The injustice by the government is also evident in the many years the case has remained unsolved while companies continue to benefit from the gold mines. The book gives insights into the case prolonged by legal maneuverings and delays perpetrating by a system that claims to protect rights. There was much irony even after the court decided the case. The Indians refused compensation in form of money and even chased their lawyers off the reservation (Treuer 67). The argument was that black hills were sacred and therefore could not be exchanged for money. In so doing, they exhibited much pride in their heritage. Even today, most Indians want the black hills returned. The voices speaking in the ‘Native America testimony’ are genuine as they are derived from statements and speeches recorded in letters from

Primary education Essay Example for Free

Primary education Essay India has made large strides in educating its population of more than a billion people, yet a lot remains to be done. It is commonplace now that education is both intrinsically valuable and also instrumental for economic well-being, and this is true for individuals and entire nations. No country in the world has been able to develop without the spread of mass education. An educated population is a prerequisite for take-off into high economic growth. Table 1 in the appendix shows literacy rates for India as a whole and by sex. It also shows the decadal rates of change from 1901 to the present. 2 Literacy rates have increased for both males and females, and though the latter continues to lag behind the former, there has been a narrowing of the male-female gap in literacy: from 24. 8% in 1991 to 21. 7% in 2001. In 2001, the absolute number of illiterates declined historically for the first time by nearly 32 million. In terms of state-wise performance, Kerala continues to occupy first rank as it has done historically; on the other hand, densely populated states like Uttar Pradesh, Rajasthan and Bihar are yet to overcome their educational inertia. 3 The average figures for India as a whole hide a great deal of variation among states. Table 2 in the appendix provides literacy rates for states for the years 1991 and 2001, for the population as a whole, by sex and also provides the decadal rate of change. In 2001, Kerala, Maharashtra and Himachal Pradesh had more than 75% of their population of 7+ years literate. On the other hand, even in 2001, less than half of Bihar’s population of seven years and above was literate with female literacy rate only 33. 6%. In terms of zones, states in the South and West outperform states in the North and East. 2. Primary Education Primary education refers to the education of children between the ages 6-11 years (grades 1-5). Universalization of Primary Education (UPE) is a constitutional provision in India and there has been a steady expansion in the spread of primary education since Indian independence in 1947. The Indian educational system is the second largest in the world after China. In 2001-02, there were nearly 0. 66 million primary schools in India 1 This study has been undertaken as part of the United Nations Millennium Development Goals Project. 2 Before the 1991 census, only those belonging to the age-group 0-4 years were excluded from the population in order to compute literacy rates and the basis of the computation was the entire population. From the 1991 census onward, literacy rates were computed based on the population aged 7+ years and above. 3 In Bihar, Nagaland and Manipur as well as Delhi and Chandigarh, the absolute number of illiterates has increased in the 1990s. 4 providing access to 84% of habitations with a primary school located within a distance of one kilometer. Between 1997 and 2002, the gross primary school enrolment rate4 for India was 111 for males and 92 for females. The net primary school enrolment rate5 on the other hand was only 78 for males and 64 for females. The net primary school attendance rate between 1999 and 2002 was 79 for males and 73 for females. However, of the children who entered primary school, only 68% reached grade 5 between 1995 and 1999 (UNICEF, 2004). Table 3 provides data on gross primary school enrolments by sex between 1950-51 and 2001-2002. As can be seen from the table there has been a steady increase in the numbers of boys and girls attending primary school over time. In Table 4, state-wise enrolment of boys and girls as a percentage of their age-group is provided for 1997-1998. Girls’ enrolment has been steadily increasing over time and in 2001-02, nearly 45% of girls in the age-group 6-11 were enrolled in school. These statistics are heartening because at least until the 1990s, one of the most dismal aspects of India’s education system was the large percentage of the population in the younger age groups that were out of school. Socio-economic disparities Despite the strong constitutional backing for the provision of primary education in India6 and its expansion over time, the system is characterized not only by low achievements but also by large unevenness of achievements. Huge gaps remain between rural and urban areas, and the probability of getting any education at all sharply depends on gender, caste and income. Women, scheduled castes and tribes and the poor are faced with formidable barriers when it comes to getting basic education. Of the 200 million children in the age group 6-14, it is estimated that 59 million are out of school. Of these 35 million are girls and 24 million are boys (Ministry of Human Development, GOI). Apart from socio-economic determinants, the educational infrastructure and the management and the governance of the educational system in India are far from efficient or sufficient. The government is the largest provider of education in India with only about 10% of primary schools owned by the private sector. 7 The quality of education provided by the public education system is low which translates into low educational abilities even for those who are able to complete primary education cycle. Moreover, there is a lot of ‘waste’ in the educational system with dropout rates as high as 40% for the country as a whole and in some Indian states, they are as high as 75%. Though the number of primary 4 Gross primary school enrolment rate is computed as the number of children enrolled in primary school regardless of age divided by the population of that age group. 5 Net primary school enrolment rate is computed as the number of children in that age group enrolled in primary school divided by the population of that age group. 6 In 2002, the Supreme Court of India decreed that free primary education was a constitutional right. 7 Around 3% of private schools are aided by the government, which makes government intervention in the education sector even greater. 5 schools in the country increased, more than 1 lakh8 habitations still do not have access to a primary school within a distance of one kilometer. Teacher-pupil ratios are inadequate: less than 2 teachers are available in rural areas to teach a class size of around 100 students. Teacher motivation and teaching incentives are also very weak. India perhaps has the highest rate of teacher truancy in the world. Poverty and Education. Empirical evidence strongly shows that, both at the level of the household as well as at the level of the country, there is a positive relationship between income (and wealth) and educational attainment. More income simply means more resources available to spend on the acquisition of education. With more than 250 million people in India living on less than a $1 a day, poverty remains a major barrier to educational access. Although education is provided ‘free’ by the government, the cost of uniforms, textbooks and transportation costs are beyond the reach of many households (Tilak, 2004). Added to these direct costs are the indirect (opportunity) costs of wage/domestic labor which children perform and the costs of acquiring education become considerable for households. Graphs 1 and 2 in the appendix show simple regressions of literacy rates for sixteen states against state poverty rates and state per capita income for 2001. As is expected, literacy rates decline with poverty and rise with per capita incomes. State per capita incomes seem to explain literacy rates better than poverty rates. Filmer and Pritchett (2001) using Demographic Health Survey data for India find that the gap in enrolment between the highest and the lowest wealth class is as much as 52 percentage points. Gupta (2003) using the 52nd round of National Sample Survey data finds that the percentage of people who have completed five years of schooling declines as one descends consumption deciles. In the lowest consumption decile, the proportion of people who have not completed the primary school cycle is greater than 80%. 9 While poverty status and income class are strong determinants of who goes to school and for how long, they do not make up the whole story. Indian states of Kerala and Himachal Pradesh even with fewer resources at their disposal have been able to achieve much better educational and health outcomes compared to rich states such as Punjab and Haryana in India. This is true even when we look at cross-country outcomes. For example, Sri Lanka and Botswana do much better in education and health terms than would be predicted based on their level of resources; the Latin American countries do much worse given their resources (Mehrotra and Jolly, 1998). 8 One lakh is equal to 100,000. 9 These graphs are meant to be illustrative of the association between resources and education and do not claim any direction of causality. The relationship between resources and educational attainment is bidirectional. The poor cannot afford schooling. With little human capital, the opportunities to escape persistent poverty are very restricted and the poor can be trapped in a low education, low income vicious cycle across generations. A large literature has analyzed both theoretically and empirically persistence of poverty inter-generationally due to lack of resources to invest in education.

Political and Migration Issues Affecting Puerto Ricans in the United St

Political and Migration Issues Affecting Puerto Ricans in the United States Puerto Ricans have a very distinct and complicated history. Their history is unlike any other immigrants who migrated at the United States at any time. Their island became a focus of the United States in 1898, when they won the island as booty in the Spanish-American war. Puerto Ricans residing in the United States have always had the dilemma of having to straddle both the American and Puerto Rican cultures and Spanish and English languages. In my opinion, Puerto Ricans have never had it easy living in the United States. So when I ask my grandparents, and other older generation Puerto Ricans why they decided to migrate from what I thought was "paradise" to the United States, they all give me the same answer. They wanted a better future for their families. They all felt that once they lived in the United States, opportunity would be knocking at the door. As exemplified in the novel, Memoirs of Bernando Vega: A Contribution to the History of the Puerto Rican Community in New York, Puerto Ricans struggled just as much in the mainland as they did on the island. Because of the relationship between the United States and Puerto Rico, one would think that Puerto Ricans would have had many advantages over other immigrants, especially after passing of the Jones Act of 1917, which granted Puerto Ricans a partial citizenship status. However, that was not the case either. Puerto Ricans still dealt with discrimination, a great deal of setbacks and downfalls, as well as issues of forced assimilation. Their high hopes of becoming successful in the United States usually came to an end after about a month or so of living in the United States when they realized it w... ...sly and were more involved politically. The difference is also due to the times in which these political groups were active, and the level of compliance Puerto Ricans had with the American political system, and improvements to individual organizations. Still there were many improvements made, and the same could not have been accomplished without Vega’s older generation of politicians. Still the efforts continue. It is now up the future generation of young Puerto Ricans to help unite their people, and their community advance. The politics of the Puerto Rican people has evolved from class politics, to ethnic politics, to what is now identity politics. In the beginning they struggled to be heard and represented in their small communities, and now we must continue to fight to have a voice and representation, not just in our community, but in the government as well.

Rh Bill Case Study Essay

There are 6 bills pertaining to reproductive health and/or population management that have been filed for deliberation in both the House of Representatives and the Senate for the 15th Congress. The most controversial of these bills is House Bill No. 96 authored by Rep. Edcel Lagman. House Bill No. 96, also known as the proposed â€Å"Reproductive Health and Population and Development Act of 2010,† will cover the following areas: * midwives of skilled attendance * emergency obstetric care * access to family planning * maternal death review * family planning supplies as essential medicines * benefits for serious and life-threatening reproductive health conditions * mobile health care service * mandatory age-appropriate reproductive health and sexuality education * responsibility of local family planning office and certificate of compliance * capability building of barangay health workers * ideal family size * employers’ responsibilities * multi-media campaign * implementing mechanisms * reporting requirements * prohibited acts * penalties The bill is controversial, as it is being opposed by concerned citizens, especially the pro-life, pro-family and pro-God groups, regardless of creed or religion. The Roman Catholic Church expresses its opposition against the bill on many counts, most especially the procurement and distribution of family planning supplies for the whole country, when the available evidence from peer reviewed medical journals supports the hypothesis that when ovulation and fertilization occur in women taking oral contraceptives (OCs) or using intrauterine devices (IUD), post-fertilization effects are operative on occasion to prevent clinically recognized pregnancy. Hormonal contraceptives and/or IUDs directly affect the endometrium. These effects have been presumed to render the endometrium relatively inhospitable to implantation or to the maintenance of the preembryo or embryo prior to clinically recognized pregnancy. These make pills and IUDS abortifacient. Pro-life groups, and many professionals in the medical and nursing fields, believe that physicians and policy makers should understand and respect the beliefs of patients who consider human life to be present and valuable from the moment of fertilization. Patients should be made fully aware of this information so that they can consent to or refuse the use of artificial contraceptives. However, the position of the Catholic Church and the pro-life groups does not mean that they espouse the attitude of â€Å"natalism† at all costs, as if the â€Å"number† of children, in itself, were the unmistakable sign of authentic christian matrimonial life. The sexual act, properly exercised within marriage only, is ordained primarily to the propagation of life. If there are reasonable motives for spacing births, such as serious medical conditions in the mother, or extreme poverty, then the Catholic Church teaches that married couples may take advantage of the natural cycles of the reproductive system and use their marriage precisely those times that are infertile (natural family planning). Other aspects of the bill being contested by concerned citizens include the classification of family planning supplies as essential medicines when their safety/toxicity profile and legal permissibility are questionable. At the same time, more importance should be given to the prevalent diseases, the top ten leading causes of morbidity and mortality in the Philippines, namely, infections such as pneumonia and tuberculosis. Financial resources allotted by foreign donors to assist the Philippine government programs could actually be better spent towards pursuing health programs targeting communicable diseases than purchasing artificial contraceptives. Very pertinent to the debate about reproduction rights is the right to life. The Philippine Constitution says that the State â€Å"shall equally protect the life of the mother and the life of the unborn from conception. If artificial contraceptives are medically proven to induce abortion as one of their mechanisms of action, then procurement and distribution of such family planning supplies are unconstitutional and illegal. INTRODUCTION The international aid environment has undergone considerable change in recent years. Internationally, principles of development cooperation. In some countries, civil society has achieved success in navigating the aid architecture and advocating effectively on behalf of sexual and reproductive health (SRH). In other countries, interacting and participating in key development processes has been more challenging due tolack of sufficient data or evidence to make a strong advocacy case, and weak understanding of terminology and processes, making access and influence difficult. For the past two years, WHO has supported the AHEAD project (completed in January 2011) implemented through the German Foundation for World Population (DSW). DSW had provided financial and technical support to civil society organisations (CSO) for developing and implementing locally devised advocacy action plans to raise levels of government funding for SRH in three countries. The countries are Bangladesh, the Philippines and Uganda. This report is a case study from the AHEAD project in Philippines. The case study begins by describing the socio political context in which the AHEAD project was implemented. The context covers three themes – an account of civil society movements, situation analysis of sexual and reproductive health and rights and background to the policy environment in the Philippines. The subsequent sections highlight findings from evaluation of the project including achievements from the implementation of the advocacy action plan, the challenges faced by AHEAD and finally the lessons learned. Literature Review The Reproductive Health Bill (RH Bill) has drawn opposing opinions from different sectors of the society. There are people who propose and support the RH Bill and there are those who strongly oppose it. Some find themselves in a crossroads wherein they agree on certain components of the RH Bill but remain doubtful about the other parts. Moral, economic and political conflicts continue to rise between opposing sectors. The debate goes on and on. The primary goal of the RH Bill is to guarantee universal access to methods and information on birth control and maternal care. There are six bills sharing common goals. There seems to be a general agreement when it comes to maternal and child health care but conflicts have risen concerning the proposal that the private sector and Filipino taxpayers fund the nationwide distribution of family planning devices to help control the country’s population. Meanwhile, the government shall continue giving out information on their uses through he alth care centers. Issues and arguments †¢ Population The Philippines has the fastest growing population in Southeast Asia. Studies have shown that most pregnancies in the Philippines, especially among the poor, are unplanned. Supporters of the RH bill claim that the increasing population of the country is something that cannot be ignored anymore. RH bill principal author Edcel Lagman said, â€Å"The Philippine population is growing at a much faster rate than can be sustained by the government or the country’s resources.†Lagman said that the Philippines is the only country in Southeast Asia that does not have a national reproductive health bill. Based on studies made by the University of the Philippines (one example here), the country tops the fertility rate in Southeast Asia at 3.3 percent. Following are Malaysia at 2.5 percent and Vietnam at 2.1 percent.

Axia College of University of Phoenix Essay

The purpose and meaning of life, is to live it in the most meaningful way a person can. I work hard on this daily, and try to show the younger generation that life can be so beautiful in a lot of positive ways if you lead it the way you want it. My personal narrative will be away to express myself like I have not done before by using theories in my readings. I am a thirty-year-old man who is very energetic, outgoing, hard working that not only values my life, but everyone else’s as well. The past five years of my life have been a five-part movie that could have big as the Lord of the Rings series. I started school, two businesses, regular job I got promoted, and bought a new house. I have had to take a back seat on being there for all my family, and friends like I am use to, because for once I had to utilize time for myself. My meaning of life stayed the same thru out these years; I think these things have made me more mature on things, and to love myself a little more. The major thing that made me really evolve in the past 5 years I believe is starting school. Six years prior to me starting at UOP I dropped out of college, because I had no clue what I wanted to use my skills for, I was very lost, unhappy, and I was doing nothing for myself it was for everyone else. That single event by enrolling back in school changed my personality over night for the better. The next day I started weeding people out of my life that where imputing nothing but negatives in it. That was defiantly the turning point for me without a doubt. This event came at the right time also in my life since I was in a very dark place at the time, so I guess you can say it was meant to be. Then I started two business ventures that I had wanted to start which proved to me that I could do something for myself to benefit my life and stability. I now have more than enough responsibilities that I did not have before, like keeping my business in order supplies to maintaining my customer relationships. My new house has been the biggest ordeal and not in a bad way it has been extremely difficult to get it to my standards, and since I am so busy I have not taking time just for my house. These challenging changes in my life now are very hard to deal with, but I would not make any changes at all, because this is the happiest I have been. I have been hard on myself, but not to the point of stressing. Happiness proves to be an interesting window through which to view continuity and change in personality (McAdams, 2006). With that said it shows in my everyday life that no matter what I am faced with today my life is a lot better now than then. I took a lot growing up without a father from not being able to afford things I wanted to not having the self-confidence in myself to make change. When you receive that unexpected high grade on a tough assignment, you are likely to feel good, and your well-being shoots way up (McAdams, 2006). Starting my businesses, buying the house, and getting promoted where some very tough assignments in the past five years, but I feel so much better about who I am with a better well being. What roles have religion, race, culture, family, and gender played in the development of my personality, well the major thing that played a role was family. My family pushed me so much to a point where failing would not be expectable in any manner. My girlfriend has never stopped believing in me she always said I will be somebody, and no one can take that from me. My race, and religion beliefs did not have a huge factor in any part of this, but my personality got me sixty percent of what I have today. Looking back on the past seeing the transition that has taking place in my life from five years ago is something in itself to boost my ego. Five years ago without UOP I can honestly say that there is no way I would be where I am now. Life is a wonderful thing to have, we make our own destiny, and being rich or poor should not make us who we are, but being in love with life and our good talents that we possess should play a huge part of what we are. McAdams, D. (2006). The person: a new introduction to personality psychology. (4th ed. ). Hoboken, NJ: John Wiley & Sons.

Extremely Loud and Incredibly Close Essay Essays

Extremely Loud and Incredibly Close Essay Essays Extremely Loud and Incredibly Close Essay Paper Extremely Loud and Incredibly Close Essay Paper Highly Loud and Incredibly Close encourages us to closely analyze the clip we have in our lives. We neer know when the last clip we will be seeing person will be. we must be responsible with how we spend our clip and we are responsible for the manner we treat people. The message that is conveyed to me an copiousness of times is to non take advantage of the clip you have. because it ?ies. This is represented on the pages with ruddy ink ( pages 208-216 ) . The commas are circled as if they are a error. Commas represent a intermission in the sentence. and with most of them circled it infers that clip moves really rapidly. The ruddy pen pages. besides represent looking closely at something. The circled ruddy pen means that there is an mistake at that place and we must look closely to ?x it. Therefore the writer wants us to closely look at the manner we distribute clip in our lives. 3 ) The alone narrative manner in Extremely Loud and Incredibly Close is chosen to further turn out certain subjects throughout the book. One manner that this book is alone is the fact that it is ?lled with symbolic pages. The space pages are a really strong manner to show the subjects in the novel. These pages exhaustively express points that Foer is seeking to do throughout the novel. Page 121 is an illustration of a clean page. conveying the changeless subject of emptiness. The clean pages represents Oskar’s grandmas head. She does non desire to believe about anything. she is enduring from loss and emptiness interior. The exposure scattered throughout the book of doorknobs conveys another large message in the book. This message is one door closes. another door opens. Even though the supporter is faced with a loss and is looking for closing. finally he obtains the closing by run intoing many new people to ?ll the empty infinite within him by literally opening new doors. This narrative manner creates a more interesting thought arousing reading experience and that is why I believe Foer has chosen to include these symbolic pages. 4 ) Oskar. his grandma. and the tenant all have loss in common. They all have a feeling of emptiness inside them. Oskar’s father â€Å"died the most atrocious decease that anyone could of all time invent† ( 201 ) . Grandmother and the tenant have both lost a boy. and Anna. Grandmother’s husband â€Å"the following forenoon he went to the airport† ( 185. ) He had left her. she had lost him. Besides the common loss that they portion. they all have issues affecting thought. The tenant and Oskar have the job of overthinking everything in their lives. The overladen pages. like page 282 express the tenants ideas overcasting up his caput. The tenant used thought as a reminder to allow him cognize he was alive during the bombardments of Dresden. He merely would believe and believe to cognize that he was alive. his encephalon was overloaded. Oskar is similar with the fact that he could neer halt his ideas. Oskar expresses that â€Å"all [ he ] wanted was to fall asleep at dark but all [ he ] could make was invent† ( 258 ) . Oskar invents many different things. like â€Å"a teakettle that reads in Dad’s voice† ( 1 ) and many other things that merely maintain traveling through his head. . Grandmother differed from them in idea. Grandmother would seek non to believe. She would compose clean pages so that she did non hold to believe about a individual thing like everything that has gone bad in her life. Although Grandmother relates to believing in the opposite manner. she still has thought in common with them.

Habits and Traits of Luna Moth, Actias luna

Habits and Traits of Luna Moth, Actias luna Although its colorful and large, this is no butterfly! The luna moth (Actias luna) is a giant silkworm moth, and although common throughout most of its range, its still a thrill to find one. What Do Luna Moths Look Like? The name luna means moon, apparently a reference to the moon-like eyespots on its wings. Theyre sometimes called moon moths, or American moon moths. These night-flying moths are also most active when the moon is high in the sky, so the name is doubly apropos. Luna moths are strongly attracted to lights, so you may see them flying around your porchlight during their breeding season (spring to early summer in the northern part of its range). When the sun rises, they often come to rest nearby, so look for them around your home in the morning. Both male and female luna moths are pale green, with long, curving tails trailing from their hindwings and light eyespots on each wing. Early season broods in the south will be darker in color, with an outer margin marked in deep pink to brown. Later southern broods and all northern broods tend to be paler in color, with an almost yellow outer margin. Males can be differentiated from females by their prominent, feathery antennae. Luna moth caterpillars are lime green with magenta spots and sparse hairs, and a pale stripe running lengthwise just below the spiracles. They reach a length of 2.5 inches (65 mm) in their final instar. How Are Luna Moths Classified? Kingdom - AnimaliaPhylum - ArthropodaClass – InsectaOrder – LepidopteraFamily - SaturniidaeGenus – ActiasSpecies - luna What Do Luna Moths Eat? Luna moth caterpillars feed on the foliage of a variety of host trees and shrubs, including walnut, hickory, sweetgum, persimmon, sumac, and white birch. Adult luna moths live only a few days, just long enough to find a mate and reproduce. Because they dont feed as adults, they lack a proboscis. The Luna Moth Life Cycle The luna moth undergoes complete metamorphosis with four life stages: egg, larva, pupa, and adult. After mating, the female luna moth oviposits on leaves of the host plant. She may produce as many as 200 eggs in total. The eggs hatch in about one week. Luna moth caterpillars feed and molt through five instars in 3-4 weeks. Once its ready to pupate, the caterpillar constructs a simple cocoon of leaves. The pupal stage lasts about 3 weeks in warmer climates. The luna moth will overwinter in this stage in colder regions, usually hidden under the leaf litter near the host tree. The luna moth usually emerges from its cocoon in the morning, and is ready to fly by evening. As adults, luna moths live just one week or less. Interesting Behaviors of Luna Moths Luna moth caterpillars employ several defensive strategies to fend off predators. First, their coloration is cryptic, so they blend in with the foliage on the host tree and make it difficult for predators to see them. Should a bird or other predator approach, they will often rear up and attempt to scare the attacker away. When that doesnt work, the luna moth caterpillar may snap its mandibles to make a clicking sound, thought to be a warning of whats coming – vomit. Luna moth caterpillars will regurgitate a foul-tasting liquid to convince potential predators that they are not at all tasty. Adult luna moths find their mates using sex pheromones. The female produces the pheromone to invite males to mate with her. Males will travel considerable distances to locate a receptive female, and mating typically occurs in the hours just after midnight. Where Do Luna Moths Live? Luna moths are found in and near deciduous hardwood forests in eastern North America. Their range extends from Canada south to Texas and Florida. Sources:Â   Actias luna – Luna Moth, Bugguide.net. Accessed online July 21, 2014.Luna Moth, Butterflies and Moths of North America website. Accessed online July 21, 2014.Luna Moth, Actias luna, University of Florida Dept. of Entomology website. Accessed online July 21, 2014.Luna Moth, Clemson University Dept. of Entomology website. Accessed online July 21, 2014.Caterpillars of Eastern North America, by David L. Wagner.

Joe Salatino, President of Great Northern American Case Study Research Paper

Joe Salatino, President of Great Northern American Case Study - Research Paper Example By this, assumption is that Joe’s employees will be prosperous because they were able to take their responsibilities, which are their capacity to attribute. Similarly, the attribute effort is because they managed time and dedicated their effort at meeting their customer base. A challenge in their tasks is mainly conquered by making necessary effort and determination. Additionally, even with significant effort, ability and role-challenge, workers have to attribute some amount of fortune. Individual mood and time should coincide with workers fortune. Discussion This discussion will investigate Joe the leader of famous Northern American firm, and his workers and how workers should comprehend the significance of how people form perception and make attributions. Joe believes that his workers have created a strong and effective relationship with their clients thought diverse techniques use in the business. The discussion will explain learning social theory, significance of the theor y in Joe’s case and the application of the theory in improving workers performance, in the company, (Martinko, 2004). Worker need to comprehend how people create opinions and make attributions because perception is a crucial process by which people choose, select, coordinate, explain, interpret and react to information. Workers are regularly exposed to diverse information, and they know when managers are deceiving. People analyze the information in their mind and organize it to create concepts regarding their experiences and senses. Different individuals perceive different cases differently based on what they selectively perceive and organize and explain what leaders and workers perceive. The attributions made by managers and workers about the causes of behaviors are crucial for behavior understanding. For instance, a manger that attributes inadequate production directly to his employees is likely to act increasingly punitively than a manager who attributes inefficient perfor mance to situations beyond the control of his subordinates. A leader who acknowledges that a worker performed poorly because she had insufficient training or skills may comprehend, and give the person adequate instructions or extra training. Comprehending the significance of how individuals form opinions and tailor attributions will aid Joe’s workers in establishing and sustaining strong, trusted and culturally solid connection with customers. Ensuring that workers realize cultural diversities and perceptions of their clients minimizes the tendency of workers unintentionally offending clients. What people consider as a sincere hand waving as a way saying Hi and goodbye can be perceived different by a person from India or Japanese. A mere index finger curling indicating, â€Å"come closer† may be interpreted by an Australian and Indonesian as prostitution solicitation. A number of people are not aware of both verbal and non-verbal social cultural differences among cultu res. Therefore, if Salatino educates his workers on factors that influence an individual’s perception, workers will have extra knowledge and expertise to create strong connections. It will also aid workers comprehend how individuals form perceptions and tailor attributions about different people, (Williams & Noyes, 2007). Some external factors that influence perception and attribution involve intensity, differences,

Marine Cargo Surveyors Research Paper Example | Topics and Well Written Essays - 1250 words

Marine Cargo Surveyors - Research Paper Example Marine surveyors have invented their personal businesses, desiring to offer their services to a number of clients and to make sure they embrace fair views in their job. In addition, they rejoice and enjoy professional independence. But others are permanent employees of the marine insurers and their clients, thus enabling the vital mediators in damage claims. As far as their training services are concerned, marine surveyors normally join the field through apprenticeship or they achieve a diploma from a technical institution or professional association in marine surveying (United States Congress, 1860). Reasons of maritime cargo surveyors According to Davies M & Force R (2005), Marine surveyors carry out hull and machinery surveys, evaluate the sale and purchase of the ship, check the general and weather conditions of before shipment and arrival of the vessel. Involve in certifying reports and progress of marine consultants, examine the classification surveys, and carry out the investi gation and surveys of loss and damages. Generally, marine surveyors’ participation therefore has to seek without relaxation once damage or loss is recognized. Additionally, the surveyor must take pleasure in uninterfered access to the interest matter of claim to ensure he may arrange every required consultant with independent professionals. Consequently, cargo surveyors are meant to perform the activities such as cargo surveys and quality inspection, sampling, damage cargo survey, inspection of agriculture products, draft surveys, investigation of contamination and shortage of bulk cargo, and supervising offloading and loading of containerized cargo. Workings of maritime cargo surveyors Marine cargo surveyors read the documents of the vessels that set forward securing procedures and cargo loading, initiate stability factors, and capacities to determine cargo capabilities according to cargo regulations and design as suggested by Nichols & Williams (2008). Marine surveyors chec k loaded, secured cargo in holds and tied to decks to determine that relevant cargo handling regulations have been surveyed. They measures depth of water and fuel in tanks as well as ship holds by using tape measure, reed drafts markings, and sounding line to determine the depth of the ship. Moreover, for surveyors to determine the volume of stored water and fuel, hold capacities, vessel stability factors and weight of the cargo, they calculate it by using calculator and mathematical standard methods. In addition to that, they examine cargoes of maritime vessels to verify compliance with international and national safety and health regulations in cargo storage and handling. Marine surveyors also issues certificates of conformity when infringements are recognized. Give crew advises in the techniques of packing heavy and dangerous cargo, like shoring, extra support beams, and extra stronger lashings, according to the skills of hazards when ferrying explosives, grain, heavy machinery a nd logs. Lastly, thy examine information achieved from survey, documents reports of research, and prepares recommendations relating to the capacity of the ship, marine surveyors help in coroners’ inquiries and attend court cases as a professional witness. Ultimately, they examine the devices of cargo handling like hoists, boom

Critically assess the elements of a successful e-commerce regulatory Essay

Critically assess the elements of a successful e-commerce regulatory model - Essay Example In the last 5 years, the government has contended that the introduction of several layers of regulation based on EU legislation into UK law has increased customer confidence in e-businesses3 and increased these businesses standards of good practice. The implementation of the Distance Selling directive into UK law was to inspire confidence and increase transactions in cross-border shopping, including the internet. The regulation cannot be contracted out and any inconsistencies between the terms of the contract and the regulations would make the contract void. It does not cover contracts relating to auctions, financial services or property and partial exemptions for accommodation, transport, catering or leisure services and goods intended for everyday consumption supplied by regular roundsmen. This information must comply with the principles of good faith in commercial transactions and the principles governing the protection of minors. However, Consumers Internationals5 research revealed that 1 in 5 sites failed to give clear total cost of the transaction despite the fact that the price of goods and services including all taxes must be provided. They have also found very few sites actually providing written information on the right to a contract withdrawal. Subject to the following exceptions , once the supplier has met his obligations relating to the provision of information, the consumer has at least 7 working days to cancel the contract without penalty (the cooling-off period6) : If the supplier fails to meet his obligations to provide information, this period is extended by 3 months. He also has 30 days to repay the amounts paid by the consumer and, in certain cases, may deduct from the refund the costs of recovering the goods. If the consumers payment card was fraudulently used, he may request cancellation of payment and reimbursement of the amounts paid. The burden of proof lies on the card issuer

Effect of Estrogen on Osteoclasts and Osteoblasts

Effect of Estrogen on Osteoclasts and Osteoblasts Osteoporosis is a disease that afflicts many people, especially women. This disease is very debilitating and is characterized by excessive bone loss which results in severe fractures. There are two types of osteoporosis: Type I and Type II. Type I is the more severe type and is prevalent in post-menopausal women. There have been numerous hypothesis and studies as to the cause of osteoporosis and its relation to menopause (Riggs, 2002). The findings suggest that estrogen plays a major role. Estrogen receptors have been identified in bone and are involved in the production and maintenance of both osteoclasts and osteoblasts (Eriksen, 1988; Girasole, 1992). Osteoclasts function in bone resorption, and osteoblasts function in synthesizing new bone, hence these two cell types have opposite effects on bone (Saladin, 2010). Studies have shown that a decrease in estrogen levels in post-menopausal women is the primary cause of this reduction in bone density (Girasole 1992; Menolagas, 2002). Estrogen is a steroid hormone that has many different functions. It is primarily involved in sexual differentiation and maturation, but also has some less obvious effects including thermoregulation and the maintenance of bone mineral deposition. Estrogen is a lipophilic hormone and therefore is capable of diffusing through the cell membrane and binding its two intracellular receptors, ERÃŽ ± and ERÃŽ ² There are three female sex hormones: estrone (E1), estradiol (E2) and estriol (E3), however, estrogen is the common name used to refer to all three, though estradiol is the main form of estrogen (Carlsten, 2005). Estrogen is mainly synthesized in the ovaries, though its synthesis is not limited to the ovaries. Some peripheral tissues, such as adipose tissue, are capable of producing estrogen by way of steroid precursors (Nelson, 2001; Simpson 1981). Synthesis of estrogen involves many different precursors the first of which is cholesterol. Cholesterol is converted in the ovarian follicle to pregnenolone which can be converted to 17ÃŽ ±-hydroxypregnenolone. 17 ÃŽ ±-hydroxypregnenolone is then converted to dehydroepiandrosterone which is converted to androstenedione which undergoes a conversion to the androgen, testosterone. Aromatase then converts testosterone to esradiol (E2). Estradiol is then secreted from the follicle and can either act on its target tissue or undergo another conversion to estrone (E1) and estriol (E3) which takes place in the liver. Estrogen has two main receptors ( ERÃŽ ± and ERÃŽ ²) that mediate its primary effects. These receptors belong to the nuclear receptor family and are transcription factors that are regulated by ligands (Carleson, 2005). Estrogen receptors require numerous coregulatory proteins that have cell-specific expressions. These cell specific expressions delineate some of the specific actions of estrogen in its various target tissues (Heldring, 2007).The two estrogen receptors maintain some highly conserved regions such as their DNA binding domains; both ERÃŽ ± and ERÃŽ ² bind the same DNA response elements. Other domains are not at all conserved, such as the amino-terminal which exhibits significant variability in sequence as well as in length. The ligand-binding domain is located at the C-terminal and is a multifunctional domain. Both the N-terminal and the C-terminal contain activation functions, AF-1 and Af-2, respectively. These activation functions, work to activate transcription by recru iting coregulatory proteins to the DNA-binding domain. Though ERÃŽ ± and ERÃŽ ² are fairly homologous, they are actually derived from separate genes which are located on separate chromosomes. ERÃŽ ± and ERÃŽ ² also give very different splice variants (Heldring, 2007). ERÃŽ ± and ERÃŽ ² regularaly act as antagonists of each other when expressed in the same cells; hence, estrogen signaling functions as a balance between these two contradictory receptors (Carleson, 2005). It appears as if ERÃŽ ² works to inhibit the effect of ERÃŽ ± by not only altering the recruitment of transcription factors essential for of ERÃŽ ±-dependent transcription, but also by increasing the degredation of ERÃŽ ± by way of ERÃŽ ²2, a splice variant of ERÃŽ ² (Heldring, 2007). Estrogen receptors have been found in many non-reproductive tissues including bone. This fact lends credence to the theory of estrogens involvement in the maintenance of bone. Estrogen Signaling There are a few distinct pathways that are involved in estrogen signaling. Three of these signaling pathways are ligand-dependent, the fourth is ligand-independent. The first ligand-dependent pathway is the classical or direct pathway (Fig. 1a.) in which the ligand (usually estradiol) binds the receptor and this ligand receptor complex then dimerizes with another ligand-receptor complex in order to bind estrogen response elements in the promoters of target genes (Carleston, 2005). The second ligand-dependent pathway is referred to as the tethered pathway (Fig. 1b.). The tethered pathway involves protein-protein interactions with transcription factors. These interactions occur after the receptor has been activated by the ligand. Hence, the receptor activates transcription by an indirect DNA binding mechanism (Carleston, 2005). The non-genomic pathway (Fig 1c.) is also ligand-dependent but is not as well understood as the previous two. It is known that the receptor is activated by the ligand, which then initiates a signaling cascade resulting in the activation of second messenger systems (Heldring, 2007). Studies have shown that the activation of these second messenger systems display some common effects including an increase in the production of cAMP levels as well as the activation of the MAPK pathway (Lim, 2006). This activation of second messenger systems ultimately leads to a rapid physiological response without involving gene regulation (Heldring, 2007). The fourth signaling pathway is ligand-independent (Fig.1d.) and involves activation by way of other signaling pathways such as that of Growth Hormone which ultimately leads to the activation of gene regulation. This activation of gene regulation occurs due to the activation of protein kinases that work to phosphorylate the estrogen receptor. This phosphorylation causes receptor dimerization which allows the receptors to then bind the DNA and activate gene transcription (Carleson, 2005; Heldring, 2007). a.) The direct ligand dependent pathway in which the ligand directly binds the receptor which dimerizes and binds the DNA promoter region. b.) The tethered pathway is indirect and involves protein interactions with transcription factors that allow for the binding of the transcription factor to the promoter region c.) The non-genomic pathway involvs activation by the ligand which then can cause a signal transduction pathway resulting in activation of second-messenger systems. d.) The ligand-independent pathwayin which activation occurs by other signalling pathways (i.e. GH) and eventually leads to activation of gene transcription. Source: Heldring, Pike, Andersson et al. Estrogen Receptors: How do they signal and What are Their Targets. Physiol. Rev. 87: 905-931. 2007. Estrogen and Osteoporosis Osteoporosis is a disease that is characterized by a decrease in bone mineral density and hence an increase in the frequency of bone fractures (Though osteoporosis is often associated with post-menopausal women, the disease is not necessarily limited by gender. Osteoporosis was separated into two classes in 1983 by Riggs and Melton. The two types of osteoporosis (Type I and Type II) differ in regions of bone mineral density, patterns of fracture, causal mechanisms and hormonal changes. Type I osteoporosis is the more severe form of osteoporosis, however, type II is more common especially in the elderly (70+) (Riggs, 2003). Type I Osteoporosis is prevalent in post-menopausal women. It usually arises within 20 years after menopause and is associated with excessive cancellous bone loss. Fractures occur at sites that are rich in cancellous bone. Type I osteoporosis is associated with an increase in osteoclast function and a decrease in osteoblast function. This is thought to be due to a decrease in the levels of estrogen present in post-menopausal women (Girasole, 1992; Ribot, 1997). Osteoporosis has been found to occur in men also; primarily elderly men. The underlying explanation for osteoporosis is that the sex steroids play a role in the remodeling process of bones. Hence, when ovarian function ceases due to menopause in women, estrogen levels decrease and bone remodeling is therefore disrupted in a deleterious fashion. Osteoporosis in men is associated with a loss of androgens which is generally due to either castration or aging (Manolagas, 2002). Type II osteoporosis is prevalent in both men and women and can occur at any age, though it is more often associated with the elderly (above age 70). Type II osteoporosis is characterized by the loss of trabecular bone. It is generally due to aging effects such as hyperparathyroidism and impaired bone formation, and also a decrease in vitamin D and PTH levels. There is some speculation as to whether or not Type II osteoporosis may also be due to late effects of decreased estrogen levels (Riggs, 2003). Evidence for estrogens involvement in osteoporosis and its actions on maintaining bone mass can be seen in the study conducted by Riggs et al. which involved 36 women with vertebral fractures due to type I osteoporosis. These women all displayed a high bone turnover rate. The women with type I osteoporosis were compared with 36 normal women (women who did not exhibit Type I osteoporosis) after they were given small amounts of the sex steroids: estradiol, estrone, and testosterone. Blood and urine samples were continuously taken (about every 24 hours) and analyzed to reveal that the levels of the sex steroids were equally apparent in both groups of women. However, the amount of all bone biochemical markers (involved in bone turnover) appeared higher in the osteoporotic women. Though the experiment did not detect a difference in the sex steroid concentrations between the two groups of women, post-experimental power calculations were done to show that there are differences between the t wo groups when ÃŽ ± = .05 and 1-ÃŽ ² = 0.8. The differences for serum estrone, estradiol and testosterone were as follows: 6.3%, 9.9%, and 4.4%, respectively. Some of the women with osteoporosis then underwent another study in which they were split into two groups. One group of osteoporotic women received one-years worth of treatment with transdermal estrogen while the other group of osteoporotic women received a years worth of treatment with a placebo. The women who underwent estrogen treatment displayed a remarkably larger decrease in bone turnover markers than the women treated with the placebo (Riggs, 2002). Osteoclasts, Osteoblasts and the Estrogen Connection Osteoclasts are cells involved in maintaing bone homeostasis and are located on the bone surface in the anterior portion where they work to digest old bone (Manolagas, 2002). Osteoclasts are derived from macrophages, and are very large multinuclear cells formed from the fusion of multiple stem cells (Saladin, 2010). Osteoclasts function in digesting bone; hence they are involved in bone resorption. Bone resorption is a process that releases calcium back into the circulatory system by digesting bone tissue (Saladin, 2010). The function of osteoclasts is essential to the broader process of bone remodeling. Osteoblasts are also involved in maintaining bone homeostasis and are active in the process of bone remodeling. Osteoblasts are located in the posterior portion of the bone surface and work to produce new bone in the areas that underwent excavation by osteoclasts (Manolagas, 2002). Osteoblasts are derived from mesenchymal stem cells (Zallone, 2006). The mesenchymal stem cells give rise to osteogenic cells which give rise to most other bone cell types including osteoblasts. Osteoblasts are immature bone cells that are located beneath the endosteum and periosteum of the bone. Osteoblasts synthesize the components of the bone matrix. The matrix undergoes mineral deposition which causes it to harden, and hence the osteoblasts become trapped within the matrix. When osteoblasts mature, they become osteocytes which function in maintaining bone (Saladin, 2010). Osteoblasts function in making new bone. They deposit calcium salts into the bone matrix in order to make hydroxyapate which is the calcium reserve in bone. Osteoblasts fill in the cavities that were excavated by osteoclasts with new bone. Osteoblasts may be stimulated by various signals and hormones such as calcitonin and estrogen which both function in decreasing blood calcium levels and maintaining calcium levels in bone (Saladin, 2010). Estrogen receptors (ERÃŽ ± and ERÃŽ ²) as well as androgen receptors (AR) have been identified in both osteoblasts and osteoclasts and their parental cells. The presence of these receptors indicates that estrogen has a direct effect in mediating the process of bone remodeling (Eriksen, 1988; Girasole, 1992; Manolagas, 2002). Estrogen and androgens also have an indirect effect on the process of bone remodeling via the cytokine, interleukin-6 (IL-6) which is an important factor in the process osteoclastogenesis in bone marrow stromal cells (Carleston, 2005; Manolagas, 2002). The Study conducted by Girasole et al. has shown that estrogen has an inhibitory effect on IL-6, which results in a decrease in the production of osteoclasts. This decrease in osteoclastogenesis ultimately causes a decrease in bone resorption (Girasole, 1992). Estrogen and androgens inhibit the production of IL-6 in vitro by inhibiting Interleukin-1 (IL-1) and tumor-necrosis factor (TNF)-ÃŽ ±. IL-1 and TNF-ÃŽ ± are involved in the synthesis of IL-6 (Ribot, 1997). Some studies suggest that estrogen has more of an effect on TNF-mediated production of IL-6, than on IL-1 mediated production (Girasole et al. 1992). The expression of the IL-6 receptor subunits, gp130 and IL-6-RÃŽ ±, are also suppressed in bone marrow stromal cells and in osteoblast progenitor cells (Manolagas, 2002). Studies done in mice have shown that when the IL-6 gene is knocked out or neutralized (via antibodies) the upregulation of colony-forming unit-granulocyte/macrophage (CFU-GM) (which osteoclasts are derived from) in bone marrow is prevented. Hence, there is not an increase in osteoclast production. The results showed that the antigen caused the estradiol-induced inhibition of bone resorption to itself be inhibited (Ribot, 1997). A decrease in estrogen (as well as androgens) also has an effect on osteoblasts. One mechanism by which osteoblasts are regulated by estrogen can be observed in bipotential stromal cells; these cells express the estrogen receptors. The bipotential stromal cells are parents to both adipocytes and osteoblasts. A study conducted by Okazaki et al. in mouse bone marrow stromal cell lines, found that estrogen works to mediate the differentiation of the parental bipolar stromal cells towards the production of osteoblasts (Okazaki, 2002). Post-menopausal women who exhibit bone loss have been observed to have an increased amount of lipid concentration in their bone marrow. Hence, a decrease in estrogen would cause an increase in adipogenesis and a decrease in osteoblastogenesis (Okazaki, 2002). This decrease in osteoblastogenesis would result in a decrease in bone formation. Estrogen Replacement Therapy A study that was conducted on post-menopausal Chinese women by Sun et al. was also useful in determining the effects of estrogen treatment for osteoporosis. These women all ranged from 41-58 years of age and had undergone menopause for more than a year. The women were split into 4 different groups. Each group received different levels of 17ÃŽ ²-estradiol (E2) gel along with a form of progesterone, either micronized progesterone (MP) or medroxyprogesterone (MPA). The progesterone was added along with the estrogen in order to prevent endometrial hyperplasia which may occur as a result of estrogen replacement therapy. The dosages differed in both progesterone type and concentration as well as in estrogen concentration. The exact dosages for each group were as follows: group 1 received 1.5 mg E2 and 100 mg MP, group 2 received 1.5 mg E2 and 2 mg MPA, group 3 received 0.75 mg E2 and 100 mg MP, and group 4 received 0.75 mg of E2 and 2 mg MPA. These dosages were administered once a day, 25 days a month for at least a year (some of the subjects were studied for two or three years). Blood and urine samples were taken from these women and monitored for bone mineral density (BMD). The results showed that after about a year of this treatment, the average increase in BMD in cancellous bone of the 4 groups ranged from 4.6%6.4%. After 36 months an increase in the BMD of the bones in the neck and the lumbar vertebrae were observed; the averages ranged from 4.3%-7.5% and 4.2%-6.2%, respectively. This study also found that the BMD in the hip (an area that is prone to fractures), had significantly higher levels than the baseline levels. The main purpose of the study was to determine an appropriate dosage of estrogen and progestin for post-menopausal Chinese women; the results of the study indicated that either 0.75 mg or 1.5 mg of E2 daily is sufficient for prevention of bone loss in Chinese women. The study suggests that hormone replacement therapy has a significant effect on bo ne, especially during the first two years of treatment (Sun, 2002). The knowledge of estrogens actions on bone and the inhibitory effect it has on osteoclastogenesis, has led to the utilization of estrogen as a treatment for osteoporosis. Estrogens ability to maintain bone mass in post-menopausal women has made estrogen replacement therapy a valuable form of treatment. This treatment utilizes the protective properties of estrogen on bone and functions in increasing bone mineral density (BMD) in post-menopausal women (Sun, 2002). Estrogens positive effects on bone are amplified during the treatment; hence, estrogen induces stimulation of osteoblastogenesis and inhibits osteoclastogenesis via IL-6 (Girasole, 1992; Okazaki, 2002). The type of estrogen administered (other than estriol) seems to have no difference in effectiveness; hence, synthetic estrogen, 17ÃŽ ²-estridiol, and equine estrogen all have equal effects on the maintenance of bone mass and all work to decrease the amount of bone turnover (Ribot, 1997). The method by which estrogen is adminis tered (i.e. transdermally, percutaneously, etc.) also does not appear to make a difference in its effectiveness. The dosages of estrogen as well as the duration of the treatment seem to be the only variables involved in determining the effectiveness of estrogen replacement therapy (Ribot., 1997). In order for estrogen replacement therapy to have a long term effect, estrogen must be administered for about 5-7 years (Cauley 1995; Ribot, 1997). Estrogen replacement therapy is also most effective if it is initiated early after menopause. A study conducted by Cauley et al. found that women who started estrogen treatment within 5 years of menopause and/or underwent treatment for 10 years or more, had the most effective and long-lasting results (Cauley 1995). Though Estrogen Replacement Therapy is a promising and effective mechanism for treatment of osteoporosis, it is associated with some serious physiological risks. Long-term usage of estrogen has been known to cause endometrial cancers. However, when estrogen is administered in conjunction with progestins, the risk of endometrial hyperplasia is significantly reduced. (Ribot, 1997; Sun, 2002). Many studies have been conducted to determine whether or not there is a relationship between estrogen and breast cancer. Some studies suggest that there is a correlation between the risk of breast cancer and use of estrogen (Lim, 2006). Other studies suggest that there is no correlation (Ribot, 1997). Though estrogen replacement therapy is associated with a few serious risks, it also has other positive physiological effects on other areas of the body, not just bone. For example, estrogen is thought to have a preventive effect on Alzheimers disease and also on Coronary Heart Disease (CHD) in post-m enopausal women (Ribot, 1997; Tang, 1996). The onset of type I osteoporosis is generally characterized by a loss of ovarian function which therefore results in a loss of estrogen in postmenopausal women. (Manolagas 2002). Estrogen can be used as a treatment for osteoporosis due to the presence of estrogen receptors in osteoclasts, osteoblasts and their precursors, as well as in bone marrow stromal cells (Zallone, 2006). The positive actions of estrogen on bone are mainly due to the suppressive actions of estrogen on bone resorption by osteoclasts (Okazaki, 2002). When Estrogen levels are decreased, the normal regeneration process, which involves bone resorption followed by an appropriate amount of bone formation, is disturbed (Zallone, 2006). Various in vitro studies have been conducted that demonstrate that the presence of estrogen (as well as androgens) increases the action of factors that work to inhibit the process of osteoclastogenesis (Bellido, 1995). The decrease in the production of osteoclasts due to estrogen would t herefore cause a decrease in the process of bone resorption (Okazaki 2002). Estrogen also has an effect on the production and differentiation of osteoblastic cells. However, it has the opposite effect on osteoblasts and thereby stimulates their production by shifting the mechanism of bipolar stromal cells towards the production of osteoblastic cells rather than that of adipocytes (Okazaki, 2006). Hence, estrogen works to decrease bone resorption and increase bone formation, thereby creating a protective effect on bone which can be utilized to treat such debilitating diseases as osteoporosis.